can someone please tell me if they have ever saved miriam ive tried and tried,it says dont lose sight of her and run after her,but you cant even see her,,help its driving me nuts

I can't say I've even played the game, but I've gathered some information that might suit you.

From what I understand, you've talked to someone called Homunculu's and you are now running around the streets. (Right!?)
Time travel to the 1980ies. YOu'll note that the era has changed name.
You've been here before so just do as you normally did, except this time you CAN chase after Miriam. Then, simply don't let her out of your sight.

Hope this is enough to help you get on with the game. If not, let us know and we'll try to help you further.

Good Luck.